Parameters
|
Group 1 (n=11)
|
Group 2
(n=19)
|
Group 3
(n=31)
|
Group 4
(n=33)
|
Group 5
(n=33)
|
p
|
Age |
31.45± 7.91 |
29.21± 6.91 |
30.68± 8.47 |
27.76± 6.71 |
29.15± 5.62 |
0.740 |
Sex (Female/Male) |
2/9 |
3/16 |
4/27 |
6/27 |
5/28 |
0.983 |
BMI |
26.59± 2.14 |
26.81± 2.46 |
27.74± 3.98 |
27.02± 3.73 |
28.25± 4.16 |
0.524 |
HIV-RNA |
0 |
13937.26± 24435.15e
|
2292.10±
3020.45b,e
|
2208.97± 5732.85b,e
|
4109.21± 12485.02b,e
|
<0.001 |
CD4 |
549.45± 55.21 |
232.74± 98.98e
|
303.29± 95.69b,e
|
299.58± 100.55b,e
|
278.24± 110.17e
|
<0.001 |
CD8 |
423± 38.30 |
370.26± 74.34 |
423.52± 97.77 |
392.85±
101.81 |
378.09± 102.72 |
0.242 |
CD4/CD8 ratio |
1.31± 0.21 |
0.63± 0.23e
|
0.71± 0.14e
|
0.75± 0.16e
|
0.71±
0.21e
|
<0.001 |
Serum Creatinine (mg/dl) |
|
|
|
|
|
|
Baseline |
0.82± 0.08 |
0.87± 0.12 |
0.91± 0.15 |
0.84± 0.13 |
0.84± 0.11 |
0.185 |
6 months |
0.84± 0.08 |
0.89± 0.14 |
0.88± 0.13 |
0.95±
0.09a,b,c
|
0.96± 0.10 a,b,c
|
<0.001 |
12 months |
0.84± 0.07 |
0.86± 0.09 |
0.89± 0.13 |
1.02±
0.08e,f,g
|
0.99± 0.07 e,f,g
|
<0.001 |
24 months |
0.86± 0.08 |
0.89± 0.06 |
0.88± 0.11 |
1.03± 0.05
e,f,g
|
1.04± 0.06 e,f,g
|
<0.001 |
CrCl (mL/min/1.73m2) |
|
|
|
|
|
|
Baseline |
106.27± 16.41 |
104.47± 21.99 |
98.13± 22.74 |
107.03± 21.08c
|
106.21± 18.35 |
0.311 |
6 months |
104.36± 21.04 |
101.26± 21.02 |
100.84± 15.49 |
89.33± 11.60a,b,c
|
89.36± 13.25a,c
|
0.002 |
12 months |
102.82± 17.77 |
103.74± 16.34 |
99.29± 19.26 |
83.21± 11.81a,f,c
|
85.06± 9.91
a,f,c
|
<0.001 |
24 months |
98.73± 16.75 |
98.16± 12.51 |
99.71± 16.36 |
81.79±
10.43a,f,g
|
80.97± 9.82 a,f,g
|
<0.001 |