AbstractIntroduction: Human Immunodeficiency virus is a chronic
infection that attacks the immune system of the human body, particularly
CD4 T lymphocytes. Combined antiretroviral therapies are highly
effective in virological suppression of human immunodeficiency virus
infection. It has been shown that some retroviral therapies have a
higher nephrotoxicity potential. As a result of renal injury, serum
creatinine increases, and the estimated glomerular filtration rate is
reduced. The aim of our study was to assess changes in kidney function
during a 24-month period in HIV-positive patients who were begun on
combined antiretroviral therapy.Material-method: A total of 127 HIV positive patients were
enrolled. The patients were divided into five groups; patients who
received no therapy were designated as Group 1; those that received
Dolutegravir/Abacavir/Lamivudine combination as Group 2; those that
received Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide
Fumarate combination as Group 3; those that received
Emtricitabine/Tenofovir Disoproxil Fumarate/Dolutegravir combination as
Group 4; and those that received Emtricitabine/Tenofovir Disoproxil
Fumarate/Raltegravir combination as Group 5. We compared the effects of
these drugs on estimated glomerular filtration rate during a 24-month
follow-up period.Results: At the 24th month of therapy, a significant difference
was observed between the eGFR levels of the study groups
(p:<0.001). eGFR level was significantly higher in Group 4
compared to Groups 1, 2, and 3 (p:0.009, p:<0.001,
p:<0.001, respectively) while it was significantly lower in
Group 5 than groups 1, 2, and 3 (p:0.005, p:<0.001,
p:<0.001, respectively). No significant eGFR difference was
found between Group 4 and Group 5 (p>0.05). Serum
creatinine level was significantly higher in Groups 4 and 5 compared to
the other groups (p<0.001).Conclusion: The use of TDF-containing regimens causes renal
dysfunction. Therefore, we recommend close monitoring of renal function,
especially in patients treated with TDF.Keywords: Human Immunodeficiency Virus, Nephrotoxicity,
Tenofovir, estimated glomerular filtration rate