CRTH2 and Leukotriene Antagonists
A subset of AERD patients may express a discrete T2 subendotype with
increased production of prostaglandin D2 (PGD2) and
cysteinyl leukotrienes compared to aspirin-tolerant T2 CRSwNP101. PGD2 activates the
chemoattractant receptor-homologous molecule expressed on Th2 cells
(CRTH2), which is important for eosinophil, basophil and lymphocyte
recruitment and activation 164. It is thus possible
that CRTH2 and leukotriene antagonists could play a more significant
role in managing patients with AERD compared to CRSwNP.