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Clinical trials in cardiac xenotransplantation: are we ready to handle ethical issues?
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  • Leonardo Rufino Garcia,
  • Flavio Brito,
  • Marcello Felicio,
  • Andre Garzesi,
  • Marcia Tardivo,
  • Bertha Polegato,
  • Marcos Minicucci,
  • Leonardo Zornoff
Leonardo Rufino Garcia
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
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Flavio Brito
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
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Marcello Felicio
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
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Andre Garzesi
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
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Marcia Tardivo
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
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Bertha Polegato
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
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Marcos Minicucci
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
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Leonardo Zornoff
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina
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Abstract

Heart allotransplantation has become one of the methods of choice in the treatment of severe heart failure. In the face of its difficulties, such as the unmet balance between organ supply and demand, the use of xenotransplantation might be an attractive option in the near future, even more with the ongoing progress achieved regarding the avoidance of hyperacute rejection and primary organ disfunction, maintenance of xenograft function and control of xenograft growth. To make possible this translational challenge, some points must be taken into account indeed, and they are the equipoise of human benefit and animal suffering, the risk of unknown infections, a well prepared informed consent, ethical and religious beliefs, and the role of cardiac xenotransplantation in a ventricular assistance device era.

Peer review status:ACCEPTED

15 Apr 2021Submitted to Journal of Cardiac Surgery
16 Apr 2021Submission Checks Completed
16 Apr 2021Assigned to Editor
16 Apr 2021Reviewer(s) Assigned
04 May 2021Review(s) Completed, Editorial Evaluation Pending
04 May 2021Editorial Decision: Revise Major
24 May 20211st Revision Received
26 May 2021Submission Checks Completed
26 May 2021Assigned to Editor
26 May 2021Reviewer(s) Assigned
08 Jun 2021Review(s) Completed, Editorial Evaluation Pending
10 Jun 2021Editorial Decision: Accept