Conclusion
Overall, the complement system needs to stay in a balanced state. Both excessive and insufficient complement activation can lead to pregnancy disorders. Our review will help us to have a more comprehensive understanding of the relationship between complement system and pregnancy. Moderate complement activities during pregnancy take part in keeping structure and immune homeostasis in placenta. Though, complement suppression strategies have been proven effective in the treatment of some pregnancy disorders 10,11 in some individual case studies. It must be emphasized that we may exert calibrated modulation, rather than complete inhibition of complement system. Our review will provide evidence for the design of complement therapy strategies for complement disorder related pathological pregnancy.