2. Complement in clearance of apoptotic cell
The complement system is an
important part of the innate immune system and play crucial role in
apoptotic cell clearance. “Eate me” signals were expressed on
apoptotic and necrotic cells surface, they attract the initiators of
complement system such as C1q, mannose binding lectin (MBL), ficolins
and trigger complement activation. C1q, MBL, and opsonins (C3b/C4b) are
all participate in phagocytosis and clearance of apoptotic cells and
necrotic debris. It is critical for development, regeneration, tissue
remodeling, and homeostasis procedures24.