Conclusion
Overall, the complement system needs to stay in a balanced state. Both
excessive and insufficient complement activation can lead to pregnancy
disorders. Our review will help us to have a more comprehensive
understanding of the relationship between complement system and
pregnancy. Moderate complement activities during pregnancy take part in
keeping structure and immune homeostasis in placenta. Though, complement
suppression strategies have been proven effective in the treatment of
some pregnancy disorders 10,11 in some individual case
studies. It must be emphasized that we may exert calibrated modulation,
rather than complete inhibition of complement system. Our review will
provide evidence for the design of complement therapy strategies for
complement disorder related pathological pregnancy.