CONCLUSION
Utilising multiple virological and immunological specimens, it is
possible to show evidence of infection much greater than those detected
from SARS-CoV-2 NPS alone. High transmission in families is associated
with detection of SARS-CoV-2 in saliva and stool, and an acute and
robust blood and saliva response which is only detected following
comprehensive assessment of biological samples. Denser sampling methods
provide a more comprehensive assessment of infection and highlights some
of the immunological differences in response between children and
adults. This profile of infection within households provides a basis for
comparison in future studies as VOC emerge.