Inflammatory responses arise as an outcome of tissues or organs exposure
towards harmful stimuli like injury, toxic chemicals or pathogenic
microorganism. It is a complex cascade of immune mechanism to overcome
from tissue injury and to initiate the healing process by recruiting
various immune cells, chemical mediators such as the vasoactive peptides
and amines, proinflammatory cytokines, eicosanoids and acute-phase
proteins to prevent tissue damage and ultimately complete restoration of
the tissue function. The cytokines plays a central role in communication
between the cells, inflammatory response initiation, amplification and
their regulation. This review will outline the importance of
inflammatory responses, the role of cytokines in inflammation and
various inflammatory disorders due to the abrupt expression of cytokines
and also highlighted the hyper-inflammatory response or cytokine storm
associated in the poor prognosis in COVID-19 pandemic.