Model selection
For model selection we used both global structure scores and interaction interface scores. This approach was described previously15, 17 and implemented in the VoroMQA web server33, but for CASP14 we introduced some modifications. These included VoroMQA-dark, a new method for global structure evaluation (see below), and an improved tournament-based ranking algorithm (see Supplementary information for details). When ranking models based on their pairwise comparisons, the algorithm puts more emphasis on the interaction interface pseudo-energy and less emphasis on the global structure score. This is achieved by using a tolerance value when comparing global VoroMQA-dark scores. If the difference between global scores is small, the interface scoring becomes the only decisive factor.
In addition to fully automated scoring methods, models were also evaluated according to constraints obtained from the literature or from the CASP contact prediction servers, if such data were available. All models were visually inspected before submission and manual ranking adjustments were introduced, if necessary.