Hybrid modeling
For some large target protein complexes structural templates were
available only for some of the subunits or domains. In these cases, a
hybrid modeling strategy was used, that is, part of the complex was
modeled using comparative modeling whereas remaining subunits were
docked to it either by template-based docking using
TM-align24 or by free docking. In addition to that, a
mixture of free docking and template-based models was submitted for
several smaller targets that had templates only from structure-based
search.