Figure 3. The expression of miR-143-3p and clinical severity of CIA mice.
DBA/1J mice were immunized with bovine type II collagen emulsified in complete Freund adjuvant and incomplete Freund adjuvant.
(A) MiR-143-3p expression in the splenic CD4+T cells of control and CIA mice detected by qPCR analysis. Data were expressed as the mean ± SEM (n=6). *p < 0.05, and ***p < 0.001 compared with the control group by Student’s t test.
(B-D) Mean arthritis score and paw thickness of control and CIA mice. Data were expressed as the mean ± SEM (n=6). * p < 0.05, **p < 0.01, by one-way ANOVA with Dunnett’s post-hoc test.