Evolutionary History Simulation
A simulation of the evolutionary history was done using the Seq-gen
software32.
We used the same tree obtained by phylogenetic inference (see
’Evolutionary Analysis’) with the JTT evolutionary model and a sequence
rich in “KK” pairs as sequence seed, in order to calculate the random
frequencies of occurrence of “KK”, “KR”, “RK” and “RR” pairs in
the tips of the phylogenetic tree.