Figure 3 A) Natural ligand binding sites on human serum albumin (HSA).
The serum albumins domains I to III and their subdomains (A and B) are
differentially colored and depicted. Additionally, the approximate
locations of the natural ligand binding sites of human albumin are
highlighted. Figure adapted from42.
B) Sites under positive selection predicted with MEME software,
exemplified on the crystallographic structure of human albumin (PDB ID
1AO6).
The high percentage of overlapping residues evolving under positive
selection and biological relevant cavities indicate that most of them
are participating in the transport, binding and/or catalytic promiscuous
activities, indicating a recent pattern of functional adaptation in the
evolution of seroalbumin.