NK cells and LXA4 inhibit superoxide production by eosinophils
As anti-inflammatory effects of LXA4 on eosinophils and NK cells were previously reported (19), we next first determined whether LXA4 was able to modulate eosinophil superoxide release. Activated eosinophils significantly reduced their superoxide release in a dose-dependent manner when exposed to LXA4 (Fig 6,A ). When eosinophils were co-incubated with NK cells in the presence of LXA4, superoxide release was still inhibited in a dose-dependent manner 4 hrs later (Fig 6, B ). This contrasts with the previously observed partial activator effect of NK cells on eosinophils (Fig 4, D ).