MATERIAL AND METHODS
A total of 318 patients who underwent RP with the diagnosis of prostate adenocarcinoma in Izmir Katip Celebi University Ataturk Training and Research Hospital between January 2009 and December 2017 were retrospectively analyzed through the hospital system. Ethics committee approval was obtained from the Non-Invasive Research Ethics Committee of Izmir Katip Celebi University.
The age, gender, preoperative biopsy results, the operation date, postoperative follow-up time, and the latest data regarding their survival were taken from the hospital system and the National Death Database. Preoperative and postoperative serum PSA values of the cases, the time from surgery to recurrence in patients with recurrence in PSA values, and treatment protocols applied to the patients were examined and recorded.
All H&E stained slides prepared from the tissues fixed with 10% formaldehyde solution and embedded in paraffin blocks were obtained from the Pathology Clinic slide storage and re-evaluated according to the Modified WHO-ISUP 2016 classification under the microscope. GSs of the cases, GG categories, HP patterns, and the percentage of these patterns, the presence of EPE, SMP, LVI, PNI, HDPIN, and tertiary patterns were evaluated and recorded. According to AJCC TNM 8th edition, pathological stages of the cases were classified as pT2, pT3a, and pT3b.
Thirty-three patients who did not come to the hospital for postoperative follow-up and were not followed up for at least 3 months or did not have two consecutive serum PSA values were excluded from the study.