Literature search methods:
The literature search was conducted through the China Knowledge Network
Data Service and Pubmed. The keywords for the Chinese literature search
were ”先天性皮肤发育不全” and ”孤立性头皮缺损”, while the keywords for
the English literature search were ”aplasia cutis congenita ”and ”scalp
defect”. Exclusion criteria: (1) Patients with congenital
dyschondroplasia syndrome. (2) Cases with unknown diagnosis and
treatment history and incomplete basic information. (3) Repeated cases
reported by the same author at the same institution.
RESULTS: A total of 12 neonates with isolated scalp defects meeting the
inclusion criteria were reported nationally and internationally from
June 2015 to June 2020 (see Table 1). Among the twelve children, five
were male. The largest scalp defect was 9.0*10.0 cm and the smallest was
0.8*1.0 cm. Two cases were treated surgically, one case was readmitted
for surgery after conservative treatment due to intracranial haemorrhage
in the child, and the rest were treated conservatively. All patients
survived and no fatal cases were reported.