Introduction:
Diffuse large B-cell lymphoma is a non-Hodgkin lymphoma (NHL) and
constitute about a third of all NHL lymphomas. It arises from a mature B
cell. Patients usually present with rapidly enlarging symptomatic mass.
They can also have “B” symptoms such as fever, weight loss and night
sweats. Evaluation is best made by excisional tissue biopsy such as
superficial lymph nodes. Diagnosis can sometimes be challenging when no
superficial lymphadenopathy is seen. Herein, we present a case of
rapidly enlarging symptomatic lung masses with extensive workup
including mediastinal lymph node biopsy which was negative for DLBCL.
Initially, PET scan did not show any superficial lymphadenopathy.
Eventually, thorough physical examination helped in unveiling the
diagnosis by excision biopsy of superficial lymph nodes.