Introduction:
Diffuse large B-cell lymphoma is a non-Hodgkin lymphoma (NHL) and constitute about a third of all NHL lymphomas. It arises from a mature B cell. Patients usually present with rapidly enlarging symptomatic mass. They can also have “B” symptoms such as fever, weight loss and night sweats. Evaluation is best made by excisional tissue biopsy such as superficial lymph nodes. Diagnosis can sometimes be challenging when no superficial lymphadenopathy is seen. Herein, we present a case of rapidly enlarging symptomatic lung masses with extensive workup including mediastinal lymph node biopsy which was negative for DLBCL. Initially, PET scan did not show any superficial lymphadenopathy. Eventually, thorough physical examination helped in unveiling the diagnosis by excision biopsy of superficial lymph nodes.