Sequence alignment
Putative homologous protein sequences were aligned with MAFFT, using
auto-parameterization (Nakamura et al. , 2018), and visualized in
Jalview (Waterhouse et al. , 2009). Alignments were manually
curated; partial sequences with substantial missing regions or anomalous
insertions in conserved regions of the protein were removed to avoid
confounding phylogenetic analyses and evolutionary model selection
(Table S3). Protein sequence alignments were trimmed to the length of
individual domains identified by NCBI’s conserved domains database
(Supplementary Datafile S1). Each domain was then re-aligned.