Conclusions
This prospective cohort study confirms the previous observations on changes in sCr values in pregnancy with thresholds for normal and abnormal values almost similar to those observed in completely different geographical and ethnic settings. The rapid decrease in early pregnancy sCr and differences across trimesters need to be taken into account during clinical practice while interpreting sCr in pregnancy. Extension of prospective studies from early pregnancy to late infancy will provide confirmatory data on the upper threshold values for sCr as a biomarker of adverse pregnancy outcomes.