Figure 5. Compound 270 alleviates the excessive biosynthesis of inflammatory cytokines induced by intraperitoneal injection of LPS in C57BL/6J mice
C57BL/6J mice, at the age of 8 weeks, randomly divided into four groups, and the mice in LPS-270-(25) and LPS-270-(50) were administered 25 mg/kg and 50 mg/kg 270 via oral gavage for 14 days. At the end of day 18, the mice were treated by intraperitoneal injection with LPS (10 mg/kg), and 24 h after LPS injection, the animals were killed (n = 6). (A) The effects of 270 on food take and body weight. (B) The effects of 270 on the liver, kidney and lung index. (C) The concentration of cytokines in the plasma was detected by ELISA. The data are presented as the means ± SEM. One-tailed Student’s t-test. *P < 0.05, **P <0.01, ***P < 0.001 compared with the LPS group.
Figure 6