RESULTS
All patients were Turkish. The mean age of the patients included in our
study was 63.89 ± 6.08. The median follow-up period of the patients was
60.0 (6.0-148.0) months. Median BCR time was 12.0 (3.0-48.0) months. The
clinical characteristics of the patients are summarized in table 1.
Patient distribution according to risk groups of predictive models was
indicated in table 2.
Overall BCR free rates at 1, 3 and 5-yr after RP was 89%, 77,9% and
75,8% respectively (Figure 1). According to D’Amico risk classification
there was statistically significant difference between risk groups in
BCR free rates at 1, 3 and 5-yr after RP (p<0.001). According
to CAPRA score categories BCR free rates at 3-yr after RP was 93.9%,
64.5% and 37.5% for low, intermediate and high risk groups
respectively. There was statistically significant difference between
risk groups in BCR free rates at 1, 3 and 5-yr after RP
(p<0.001). In addition, there was statistically significant
difference between risk groups of GP score in BCR free rates at 1, 3 and
5-yr after RP (p<0.001). For PRIX we combined patients with a
score of 3, 4 and 5 because there were few patients with these scores.
There was statistically significant difference between score groups of
PRIX score in BCR free rates at 1, 3 and 5-yr after RP
(p<0.001) (Figure 2).
In our study, the accuracy of four prognostic models were calculated
according to Harrell’s concordance index. The Harrell’s concordance
index for 1-yr BCR predictions was 0,802, 0,831, 0,773 and 0,745 for the
GP score, PRIX, CAPRA and D’Amico and respectively. For 3-yr BCR
predictions it was 0,798, 0,791, 0,723 and 0,714 for the GP score, PRIX,
CAPRA and D’Amico and respectively. Finally, The Harrell’s concordance
index for 5-yr BCR predictions was 0,778, 0,771, 0,702 and 0,693 for the
GP score, PRIX, CAPRA and D’Amico and respectively.