RESULTS
All patients were Turkish. The mean age of the patients included in our study was 63.89 ± 6.08. The median follow-up period of the patients was 60.0 (6.0-148.0) months. Median BCR time was 12.0 (3.0-48.0) months. The clinical characteristics of the patients are summarized in table 1. Patient distribution according to risk groups of predictive models was indicated in table 2.
Overall BCR free rates at 1, 3 and 5-yr after RP was 89%, 77,9% and 75,8% respectively (Figure 1). According to D’Amico risk classification there was statistically significant difference between risk groups in BCR free rates at 1, 3 and 5-yr after RP (p<0.001). According to CAPRA score categories BCR free rates at 3-yr after RP was 93.9%, 64.5% and 37.5% for low, intermediate and high risk groups respectively. There was statistically significant difference between risk groups in BCR free rates at 1, 3 and 5-yr after RP (p<0.001). In addition, there was statistically significant difference between risk groups of GP score in BCR free rates at 1, 3 and 5-yr after RP (p<0.001). For PRIX we combined patients with a score of 3, 4 and 5 because there were few patients with these scores. There was statistically significant difference between score groups of PRIX score in BCR free rates at 1, 3 and 5-yr after RP (p<0.001) (Figure 2).
In our study, the accuracy of four prognostic models were calculated according to Harrell’s concordance index. The Harrell’s concordance index for 1-yr BCR predictions was 0,802, 0,831, 0,773 and 0,745 for the GP score, PRIX, CAPRA and D’Amico and respectively. For 3-yr BCR predictions it was 0,798, 0,791, 0,723 and 0,714 for the GP score, PRIX, CAPRA and D’Amico and respectively. Finally, The Harrell’s concordance index for 5-yr BCR predictions was 0,778, 0,771, 0,702 and 0,693 for the GP score, PRIX, CAPRA and D’Amico and respectively.