What this study adds?
Voriconazole Cminss in the low concentration group
(Cminss<1.0mg/L) may be associated withCYP2C19 DNA methylation, which was not found in the high
concentration group (Cminss>5.5mg/L).
CYP2C19 DNA methylation is a new perspective for interpreting
voriconazole Cminss variation between/within
individuals.