2.5 Data collection
Information collected from patients’ electronic medical records includes
demographic information, medical history, and laboratory parameters.
Information collected from a patient’s electronic medical record
includes demographic information, medical history, and laboratory
parameters. Demographic characteristics include age, sex, BMI. The
medical history information included the diagnosis and treatment level
of IFD, the underlying disease, the route and dose of voriconazole
administration, and the combination of medications within one week.
Laboratory tests include markers of inflammation (C-reaction protein
(CRP), procalcitonin (PCT)), blood routine parameters (white blood cell
count (WBC), neutrophil count (NEUT), red blood cell count (RBC),
hemoglobin (RBC), and blood cell count (WBC) respectively. HB),
hematocrit (HCT), and platelet count (PLT); Liver function indicators
(alanine transaminase (ALT), aspartate aminotransferase (AST), total
bilirubin, T-BIL), albumin (Alb), total protein (TP), and alkaline
phosphatase (ALP); Indicators of renal function (serum creatinine (SCr),
Urea, estimated glomerular filtration rate (GFR)).Methylation degree ofCYP2C19 CpG site, voriconazole and voriconazole N -oxide
concentration were recorded.