What this study adds?
Voriconazole Cminss in the low concentration group (Cminss<1.0mg/L) may be associated withCYP2C19 DNA methylation, which was not found in the high concentration group (Cminss>5.5mg/L). CYP2C19 DNA methylation is a new perspective for interpreting voriconazole Cminss variation between/within individuals.