FIGURE LEGENDS
Figure 1. (A, B) Gene ontology (GO) biological process analysis of upregulated (A) and downregulated (B)genes. The x-axis shows the gene ratio of the overlapping genes of our gene list with the pathway gene set. The colour bar represents the adjusted p-value and the circle size is the count of overlapping genes.(C, D) Boxplots display log2 expression values for six pOIT genes (C : upregulated, D : downregulated) throughout the treatment protocol at FDR p<0.05. Red box: pOIT start, green box: Maintenance, blue box: Final. ORA = Over-representation analysis.
Figure 2. Overlap of 108 genes from the FASTX pOIT study with the peanut-related genes found in Watson et al . at nominal p<0.005. The y-axis represents changes in gene expression between the means at baseline and the four-hour time point of the peanut challenge in Watson et al , and the x-axis is effect size estimates from the mixed-effect model in the FASTX pOIT study. The green colour shows opposite direction, and the pink same direction.