CNIs options Superiority compared to TAC/ CsA Conditions may consider switching TAC to CsA
CsA
Lower rate of new-onset diabetes after transplant (NODAT)[9] May have lower neurotoxicity[10] Reduced the risks after liver transplantation of death, graft loss, acute rejection and steroid-resistant rejection[9, 11] The serum concentration of TAC is low and unable to reach the target serum concentration after increasing the dose of TAC. Severe complications developed such as posterior reversible encephalopathy syndrome (PRES), seizures and some other CNS symptoms.[12, 13]
TAC Easier to achieve the balance between efficacy and side effects[9]