Patients and study design
Patients who received pediatric LT from 2006 to 2019 at RenJi Hospital,
Shanghai Jiaotong University School of Medicine were included in this
study. Patients with loss of follow-up or death within the first month
after operation were excluded from this study. All the patients were
follow-up until the study end date of December 2019. All pediatric LT in
this study received approval from Shanghai Jiaotong University School of
Medicine, Renji Hospital Ethics Committee. No organs from executed
prisoners were transplanted and reported in this study. This
retrospective study was performed following the declaration of Helsinki
guidelines.
To analyzed risk factors of switching IS drugs after pediatric LT,
patients were divided into two groups: patients with switching IS drugs
and patients without switching IS drugs. Data of recipients were
collected from our maintained database of liver transplantation. Patient
characteristics including demographics, comorbidities,
pre-operative lab values, outcome
based on post-transplantation events were compared between the two
groups.