3D structural modeling of the human CENP-HIK
High-quality 3D structural models of the hs CENP-H, -I, and -K were individually predicted using the RaptorX Contact tool [32]. RaptorX Contact predicts contacts through the integration of both sequence conservation and evolutionary coupling information by using an ultra-deep neural network formed by two residual neural networks. Different forms of 1-dimensional sequential feature transformation is conducted by the first residual network while the second conducts different types of 2-dimensional pairwise information transformation which include, pairwise potential, first residual network output, and evolutionary coupling information. Through the use of these very deep residual networks, RaptorX Contact accurately models patterns of contact occurrence and complex sequence-structure relationship [32].