Chain(s) |
Position |
Wild-type residues |
Mutant residues |
ΔΔGAffinity
(Kcal/mol) |
Effect |
H |
219 |
LEU |
ALA |
-1.387 |
Decreasing affinity |
H |
225 |
VAL |
ALA |
-0.22 |
Decreasing affinity |
H |
233 |
LEU |
ALA |
-0.427 |
Decreasing affinity |
H |
234 |
LYS |
ALA |
-2.149 |
Decreasing affinity |
H |
238 |
LEU |
ALA |
-1.091 |
Decreasing affinity |
M |
94 |
LEU |
ALA |
-1.615 |
Decreasing affinity |
M |
163 |
LEU |
GLU |
-1.19 |
Decreasing affinity |