Table 4. The MutaBind2 mutation-induced change in binding
affinity prediction. The input requires the PDB structure of the protein
complex with a minimum of 2 distinct chains. A negative and positive
ΔΔGbind (kcal/mol) value correspond to stabilizing and
destabilizing mutations, predicted to increase and decrease the binding
affinity respectively. An all-positive value for the MutaBind2 output
denote a destabilizing effect on the protein-protein interaction.