3D structural modeling of the human CENP-HIK
High-quality 3D structural models of the hs CENP-H, -I, and -K
were individually predicted using the RaptorX Contact tool [32].
RaptorX Contact predicts contacts through the integration of both
sequence conservation and evolutionary coupling information by using an
ultra-deep neural network formed by two residual neural networks.
Different forms of 1-dimensional sequential feature transformation is
conducted by the first residual network while the second conducts
different types of 2-dimensional pairwise information transformation
which include, pairwise potential, first residual network output, and
evolutionary coupling information. Through the use of these very deep
residual networks, RaptorX Contact accurately models patterns of contact
occurrence and complex sequence-structure relationship [32].