Chemokine & cytokine, Wnt, CCKR, EGR receptor and PDGF signalling pathways are enriched in host proteins of linear pairs
The enriched pathways and processes of the host primarily imitated by pathogens during infection were annotated. Apart from specific pathways for some autoimmune diseases such as Huntington and Alzheimer, Chemokine & cytokine, Wnt, CCKR (Cholecystokinin receptor), EGF (Epidermal Growth Factor) receptor, PDGF (Platelet-derived growth factor) signalling pathways and T-cell and B-cell activation pathways were enriched among the host proteins constituting the DLPs and MLPs (Figure 5). Thus, signalling pathways of the hosts are most commonly targeted by the pathogens for molecular mimicry.
The host proteins were further annotated using gene ontologies. The enriched cellular compartments found were cellular anatomical entities, protein-containing complex and intracellular. As shown in Supplementary Figure S1 and S2, the enriched molecular functions found were binding, catalytic activity, molecular function regulator while enriched biological processes found were cellular process, metabolic process and signalling.