Chemokine & cytokine, Wnt, CCKR, EGR receptor and PDGF signalling
pathways are enriched in host proteins of linear pairs
The enriched pathways and processes of the host primarily imitated by
pathogens during infection were annotated. Apart from specific pathways
for some autoimmune diseases such as Huntington and Alzheimer, Chemokine
& cytokine, Wnt, CCKR (Cholecystokinin receptor), EGF (Epidermal Growth
Factor) receptor, PDGF (Platelet-derived growth factor) signalling
pathways and T-cell and B-cell activation pathways were enriched among
the host proteins constituting the DLPs and MLPs (Figure 5). Thus,
signalling pathways of the hosts are most commonly targeted by the
pathogens for molecular mimicry.
The host proteins were further annotated using gene ontologies.
The enriched cellular compartments
found were cellular anatomical entities, protein-containing complex and
intracellular. As shown in Supplementary Figure S1 and S2, the enriched
molecular functions found were binding, catalytic activity, molecular
function regulator while enriched biological processes found were
cellular process, metabolic process and signalling.