Linear pairs in highly interacting pathogen proteins and host proteins
Several previous studies have shown that essentiality and pathogen fitness are correlated with high number of interactions (78, 79). Therefore, the number of DLPs and MLPs in the top 10 highly interacting pathogen proteins and host proteins were examined and are listed in Table 6 and Table 7 respectively. The top 10 highly interacting pathogen proteins were of viral origin and predominantly formed MLPs, indicating that local sequence similarities predominate the mimicry of host proteins by pathogens. Among host proteins, a few had a very high number of DLPs. As shown in Table 7, Nuclear factor NF-kappa-B p105 subunit was a part of 491 while Cellular tumor antigen p53 was a part of 180 DLPs.