HP-PPI data
After collection and processing of the HP-PPI data, it was found that viruses have the highest number of reported HP-PPIs among the different pathogen categories. After data collection and cleaning, 5,569 pathogen proteins from 630 organisms interacted with 10,078 host proteins with 61,215 HP-PPIs. There were 49,249 reported unique HP-PPIs of viral origin. In comparison, reported bacterial HP-PPIs were 10,080 while those from other organisms were even fewer. Further, 11,657 host first interactors having 1,03,120 interactions with the host proteins were retrieved as described in the Methodology. Domains and motifs of these first interactors were identified and compared with those present in the pathogen proteins.