*Partially adjusted model includes age at enrollment, sex, insurance,
maternal history of asthma and season of exam.
†Fully adjusted model includes age at enrollment, sex, median household
income by ZIP code, insurance, maternal history of food allergy,
maternal history of asthma, age at early childhood exam, geographic
region of residence at exam, and season of exam.
REFERENCES
1. Robinson LB, Chen Arroyo AJ, Dantas MAS, Espinola JA, Sullivan AF,
Camargo CA, Jr. Prenatal exposure to acid suppressant medications and
the risk of recurrent wheeze at 3 years of age in children with a
history of severe bronchiolitis. J Allergy Clin Immunol Pract. 2019
Sep-Oct;7(7):2422-2424.e4.
2. Lai T, Wu M, Liu J, Luo M, He L, Wang X, et al. Acid-suppressive drug
use during pregnancy and the risk of childhood asthma: A meta-analysis.
Pediatrics. 2018 Feb;141(2):e20170889
3. Devine RE, McCleary N, Sheikh A, Nwaru BI. Acid-suppressive
medications during pregnancy and risk of asthma and allergy in children:
A systematic review and meta-analysis. J Allergy Clin Immunol.
2017;139(6):1985-8.e12.
4. Untersmayr E. Acid suppression therapy and allergic reactions.
Allergo J Int. 2015;24(8):303-11.
5. Robinson LB, Camargo CA, Jr. Acid suppressant medications and the
risk of allergic diseases. Expert Rev Clin Immunol. 2018;14(9):771-80.
6. Hasegawa K, Mansbach JM, Ajami NJ, Espinola JA, Henke DM, Petrosino
JF, et al. Association of nasopharyngeal microbiota profiles with
bronchiolitis severity in infants hospitalised for bronchiolitis. Eur
Respir J. 2016;48(5):1329-39.
7. Untersmayr E, Bakos N, Scholl I, Kundi M, Roth-Walter F, Szalai K, et
al. Anti-ulcer drugs promote IgE formation toward dietary antigens in
adult patients. FASEB J. 2005;19(6):656-8
8. Untersmayr E, Schöll I, Swoboda I, Beil WJ, Förster-Waldl E, Walter
F, et al. Antacid medication inhibits digestion of dietary proteins and
causes food allergy: a fish allergy model in BALB/c mice. J Allergy Clin
Immunol. 2003;112(3):616-23.
9. Pascal M, Perez-Gordo M, Caballero T, Escribese MM, Lopez Longo MN,
Luengo O, et al. Microbiome and allergic diseases. Front Immunol.
2018;9:1584.
10. Levy EI, Hoang DM, Vandenplas Y. The effects of proton pump
inhibitors on the microbiome in young children. Acta Paediatr.
2020;109(8):1531-8.