Analytical technique ELISA ELISA ELISA ECLIA CLIA CLIA LFI
Epitope Anti-RBD Anti-S1 Anti-N Anti-N Anti-N Anti-S1/S2 Anti-RBD+
Antibody subtype IgG IgG IgG Pan-Ig IgG IgG Pan-Ig
Manufacturer In-house Euroimmun Epitope diagnostics Roche diagnostics Abbott DiaSorin Bühlmann
Numbers of patients 3’637 3’658 3’654 3’630 3’630 3’630 2’589
True positives 152 168 126 164 153 160 110
False negatives 40 27 66 25 36 29 21
False positives 98 62 79 54 60 84 95
True negatives 3’347 3’401 3’383 3’387 3’381 3’357 2’363
AUC (95% CI)
0.95 (0.93, 0.97) 0.97 (0.95, 0.98) 0.90 (0.86, 0.93) 0.94 (0.91, 0.97) 0.95 (0.93, 0.98) 0.95 (0.92, 0.97) 0.92 (0.88, 0.95)
Sensitivity (percent; 95%CI) 79.2 (72.7, 84.7) 86.2 (80.5, 90.7) 65.6 (58.4, 72.3) 86.8 (81.1, 91.3) 81.0 (74.6, 86.3) 84.7 (78.7, 89.5) 84.0 (76.6, 89.8)
Specificity (percent; 95%CI) 97.2 (96.5, 97.7) 98.2 (97.7, 98.6) 97.7 (97.2, 98.2) 98.4 (98.0, 98.8) 98.3 (97.8, 98.7) 97.6 (97.0, 98.1) 96.1 (95.3, 96.9)
Positive likelihood ratio 28 48 29 55 46 35 22
Negative likelihood ratio 0.21 0.41 0.35 0.13 0.19 0.16 0.17