ORIGINAL ARTICLE
Serological testing for SARS-CoV-2 antibodies in clinical practice: a comparative diagnostic accuracy study
Michael P. Horn, PhD1*, Hulda R. Jonsdottir, PhD2,3,8*, Daniel Brigger, PhD 2,3, Lauro Damonti, MD4,5, Franziska Suter-Riniker, PhD6, Olga Endrich, MD7, Tanja K. Froehlich, PhD1, Martin Fiedler, MD1Carlo R. Largiadèr, PhD1, Jonas Marschall, MD4, Benjamin Weber, PhD8, Alexander Eggel, PhD2,3, Michael Nagler, PhD1,3
1 University Institute of Clinical Chemistry, Inselspital University Hospital, 3010 Bern, Switzerland;2 Department of Rheumatology, Immunology, and Allergology, Inselspital University Hospital, 3010 Bern, Switzerland;3 Department of BioMedical Research, University of Bern, 3012 Bern, Switzerland; 4 Department of Infectious Diseases, Bern University Hospital, and University of Bern, 3012 Bern, Switzerland; 5 Ente Ospedaliero Cantonale, Division of Infectious Diseases, Regional Hospital Lugano, 6900 Lugano, Switzerland; 6 Institute for Infectious Diseases, University of Bern, 3012 Bern, Switzerland; 7 Medical Directorate, Inselspital, University Hospital of Bern, 3010 Berne, Switzerland; 8 Spiez Laboratory, Federal Office for Civil Protection, 3700 Spiez, Switzerland
* contributed equally
Correspondence: Michael Nagler, MD, PhD, MSc; michael.nagler@insel.ch;
phone +41 31 664 0520; fax +41 31 632 4862
Keywords : Infections/*epidemiology/transmission *Disease Outbreaks; spike protein, SARS-CoV-2 [Supplementary Concept]; severe acute respiratory syndrome coronavirus 2 [Supplementary Concept]; COVID-19 diagnostic testing [Supplementary Concept]
Running head: Serological testing for COVID-19
Word counts: text = 3940; abstract = 417; References = 38; Figures = 6; Tables = 4