2.3. Statistical Analysis:
Mean and standard deviation were used to describe quantitative data and
frequency and percentage were used to describe categorical data. ANCOVA
test was used to evaluate the effect of silymarin on quantitative
variables (EORTC QLQ and VAS) so that the final EORTC QLQ and VAS scores
were used as the main factor and adjusted based on the initial score.
Chi-square test was used to describe the qualitative outcomes (e.g.,
severity of neuropathy and number of patients improved). All tests were
calculated at 95% significance level using SPSS software version 21.