Main Findings
In this study, we observed an increase in placental histopathological
lesions in women who screened high risk for lifetime CVD at 6 months
postpartum following a PE pregnancy. Specifically, high-risk women had
more severe lesions of MVM, the placental pathology traditionally
associated with PE. MVM lesions with a severity score >2 or
more resulted in a 3-fold increased risk of screening high risk for
lifetime CVD at 6 months postpartum. The cumulative severity of MVM
lesions was important in this association, suggesting that there may be
critical thresholds of placental damage that reflect increased lifetime
cardiovascular risk.