Main Findings
In this study, we observed an increase in placental histopathological lesions in women who screened high risk for lifetime CVD at 6 months postpartum following a PE pregnancy. Specifically, high-risk women had more severe lesions of MVM, the placental pathology traditionally associated with PE. MVM lesions with a severity score >2 or more resulted in a 3-fold increased risk of screening high risk for lifetime CVD at 6 months postpartum. The cumulative severity of MVM lesions was important in this association, suggesting that there may be critical thresholds of placental damage that reflect increased lifetime cardiovascular risk.