Placental Lesion
High CVD Risk (n= 53) Low CVD Risk (n= 32) P-value (Pearson X2)
Evidence of maternal vascular malperfusion Evidence of maternal vascular malperfusion Evidence of maternal vascular malperfusion Evidence of maternal vascular malperfusion
Placental infarction 16 (30.2) 7 (21.9) 0.403
Distal villous hypoplasia 15 (28.3) 8 (25.0) 0.740
Accelerated villous maturation 31 (58.5) 12 (37.5) 0.061
Syncytial knots 34 (64.2) 17 (53.1) 0.315
Perivillous fibrin deposition 5 (9.4) 6 (18.8) 0.215
Villous agglutination 7 (13.2) 1 (3.1) 0.123
MVM Score 1 or less 8 (15.1) 9 (28.1) 0.146
MVM Score 2 or more 29 (54.7) 9 (28.1) 0.017
Evidence of maternal decidual arteriopathy Evidence of maternal decidual arteriopathy Evidence of maternal decidual arteriopathy Evidence of maternal decidual arteriopathy
Insufficient vessel remodeling 7 (13.2) 2 (6.3) 0.312
Fibrinoid necrosis 4 (7.5) 2 (6.3) 0.821
Decidual arteriopathy present 9 (17.0) 3 (10.3) 0.416
Evidence of ascending intrauterine infection Evidence of ascending intrauterine infection Evidence of ascending intrauterine infection Evidence of ascending intrauterine infection
Maternal inflammatory response 2 (3.8) 4 (4.7) 0.128
Fetal inflammatory response 2 (3.8) 2 (6.3) 0.601
Ascending intrauterine infection present 3 (5.7) 5 (15.6) 0.127
Evidence of placenta villous maldevelopment Evidence of placenta villous maldevelopment Evidence of placenta villous maldevelopment Evidence of placenta villous maldevelopment
Chorangiosis 0 (0) 0 (0)
Chorangiomas 0 (0) 0 (0)
Delayed villous maturation 1 (1.9) 2 (6.3) 0.291
Evidence of fetal vascular malperfusion Evidence of fetal vascular malperfusion Evidence of fetal vascular malperfusion Evidence of fetal vascular malperfusion
Avascular fibrotic villi 2 (3.8) 0 (0) 0.266
Thrombosis 1 (1.9) 1 (3.1) 0.715
Intramural fibrin deposition 0 (0) 3 (9.4) 0.023
Karyorrhexis 0 (0) 0 (0)
High-grade fetal vascular malperfusion 2 (3.8) 0 (0) 0.266
Fetal vascular malperfusion present 4 (7.5) 5 (15.6) 0.241
Fibrinoid Fibrinoid Fibrinoid Fibrinoid
Increased focal perivillous fibrin deposition 2 (3.8) 2 (6.3) 0.601
Massive Perivillous fibrin deposition pattern 1 (1.9) 0 (0) 0.434
Maternal floor infarction pattern 0 (0) 0 (0)
Intervillous thrombi Intervillous thrombi Intervillous thrombi Intervillous thrombi
Intervillous thrombi 5 (9.4) 1 (3.1) 0.271
Evidence of chronic inflammation Evidence of chronic inflammation Evidence of chronic inflammation Evidence of chronic inflammation
Villitis of unknown etiology 5 (9.4) 3 (9.4) 0.993
Chronic intervillositis 0 (0) 0 (0)
Chronic plasma cell deciduitis 5 (9.4) 3 (9.4) 0.993
Chronic inflammation present 7 (13.2) 6 (18.8) 0.492