Association of placental lesions and CVD risk
Individually, no placental lesions were found to be significantly associated with high-risk CVD screening at 6 months postpartum. However, PE women with lesions of MVM with a severity score of 2 or more were more likely to screen high-risk for lifetime CVD than PE women without severe MVM lesions (severity score <2) [OR 3.10 (1.20-7.92)]. Severity of MVM lesions (score 2 or more) was moderately predictive of high-risk screening at 6 months postpartum (AUC 0.63 (0.51, 0.75); sensitivity: 71.8% [54.6, 84.4]; specificity: 54.7% [41.5, 67.3]) (Figure 1) . When clinical data (maternal age, gestational weight gain, blood pressure at delivery, gestational age at delivery) was added, the model’s predictive performance improved marginally (AUC 0.73 (0.62, 0.84) sensitivity 78.4% [65.4, 87.5]; specificity 51.6% [34.8, 68.0]) (Figure 1) .