Figure 6. Counts and frequency distribution of clonotypes. (A).Detection times of each clonotype in TIL samples. X axis indicates the number of samples having the same clonotype. Y axis indicates the cumulative number of clonotypes. Clonotypes were determined by the combination of CDR3 sequence, V gene and J gene. The cumulative number of shared clonotypes were highlighted in the zoomed subplot. Clonotypes detected in more than one TIL samples were considered as shared clonotypes. 1.53% clonotypes were detected in more than one TIL samples, and 0.01% clonotypes were detected in 4-6 TIL samples.(B). Reads fraction of shared clonotypes is shown as table. The reads fraction ranges at which these shared clonotypes were represented in their respective TIL samples were summarized in the left column. The clonotype number in each category and their corresponding percentage in total clonotype numbers were shown in the middle and right column, respectively.