Statistical analysis
Statistical analyses were performed using Prism 7.0 (GraphPad Software) and R 4.1.0. Bar or dot graphs indicate means ± SEM. Non-paired t test (two-tailed) was used for the comparison between CC and VC datasets. datasets. P values are marked in the corresponding figures and two side p values < 0.05 were considered as statistically significant. Vegan package in R software were utilized to calculate Shannon-Weaver index of TCR CDR3 sequence.