Diagnostic and prognostic value of CD4+ T cell
OX40 and sOX40L expression in patients with MG
We generated a receiver operating characteristic (ROC) curve using the
expression data from patients with RSMG and patients with PSMG to
evaluate the diagnostic and prognostic value of OX40 and sOX40L levels
in CD4+ T cells. The area under the ROC curve for the
CD4+ T cell OX40 index was 0.805 [95%
confidence interval (CI):
0.688–0.922, P =0.000], the sensitivity was 59%, and the
specificity was 93% (Fig. 4E ). The area under the ROC curve
for the sOX40L index was 0.784 (95% CI: 0.671–0.898, P =0.000),
the sensitivity was 68%, and the specificity was 90% (Fig.
4G ). The results indicated that OX40 and sOX40L levels in
CD4+ T cells have moderate predictive value in
monitoring recurrence in patients with MG.