Results
OX40/OX40L expression was increased on lymphocytes in the
peripheral blood from
patients with MG
Flow cytometry was used to analyze the expression of OX40 and OX40L on
the peripheral blood lymphocytes of all subjects. The expression of OX40
on CD4+ T cells in the MG group was significantly
higher than that in the HC group (Fig. 1A, B ). Compared with
the HC group, OX40L expression was significantly increased on
CD19+ B cells and CD14+ monocytes
from the MG group (Fig. 1A, C, D ). The levels of mOX40 and
mOX40L in the MG group and HC group are presented inSupplementary Table 4 .
OX40 was expressed at significantly higher levels on
CD4+ T cells from the USMG, RSMG and PSMG groups than
on cells from the HC group. Compared with the USMG and PSMG groups, OX40
expression on CD4+ T cells from the RSMG group was
significantly increased (Fig. 3A, B ). OX40L expression on
CD19+ B cells was significantly increased in the PSMG
group compared with the HC group (Fig. 3A, C ).
Higher expression of OX40L was
detected on CD14+ monocytes from the RSMG group than
on cells from the HC group (Fig. 3A, D ). However, no
significant difference in OX40L expression on CD19+ B
cells and CD14+ mononuclear cells was observed among
the USMG, RSMG and PSMG groups. The levels of mOX40 and mOX40L in
patients with different stages of MG are shown in Supplementary
Table 6 .