Discussion
To reduce hyperphosphatemia in dialysis dependent patients there are different oral phosphate binders available. As compared with other phosphate binders, Lanthanum carbonate does not show an increased risk for all-cause mortality or malignancy while maintaining a similar effect of reducing serum phosphate levels. However, 17.8% of patients showed gastrointestinal symptoms that required hospitalization. Unspecific gastrointestinal symptoms, like emesis, are the most common adverse effects. The oral bioavailability is 0.001% and is mostly eliminated through the gastrointestinal tract where it forms insoluble complexes with ingested phosphate. Since 2015 numerous case reports and a few studies showed an association with lanthanum carbonate intake and lanthanum phosphate deposition especially in the gastric mucosa. Nevertheless, the accumulation mechanism is not entirely understood. Lanthanum carbonate is soluble at resting gastric pH-levels which could be a way of penetrating the gastric mucosa. Chronic kidney disease patients also have a disruption of the epithelial tight junctions in the gastrointestinal tract which leads to a higher permeability for substances like lanthanum. Lanthanum carbonate is radiopaque. In abdominal CT, a high-density linear appearance (HD-LA), can be found in 60% - 79%, and is seen as a correlate for gastric lanthanum depositions. Yabuki et al. suggest using the HD-LA as a screening criterion. Whereas Namie et al. described a continuing HD-LA in CT after 8 months of discontinuation, our patient didn’t show radiopaque objects in an abdominal radiograph, but radiographs may not be as sensitive to slight lanthanum depositions as a CT might be. Further studies are needed to investigate if abdominal radiographs and CTs can be used as a screening method. Endoscopically the depositions appear as whitish mucosal lesions that vary in shape and size. Although Shitomi et al. found that those distinctive endoscopic observations might be difficult to detect in a case with slight depositions. This is why Iwamuro et al. suggest taking biopsies also in cases without an endoscopic correlate because they found lanthanum depositions by histology in endoscopically normal mucosa.
The histologic correlate to the whitish discoloration are histiocytes containing brownish foreign bodies in the lamina propria. In an early stage of deposition, the macrophages are arranged singly or in small clusters, whereas in later stages they diffusely infiltrate the mucosa. The macrophages in our specimen showed a diffuse infiltration pattern, which fits with a later stage accumulation. Nakamura et al. suggest that M2-polarised macrophages play a crucial role for the clearance of lanthanum. Lanthanum is likely to be resistible to intracellular digestion, so histiocytic activation with following tissue damage is conceivable. The endoscopic features show a significant relationship with the degree of histiocytic infiltration. Hattori et al. found that the histiocytic infiltration is specific for lanthanum deposition. The daily dose of lanthanum carbonate positively correlates with lanthanum deposition in the mucosa. Various histopathological changes are described with lanthanum depositions. Most often metaplastic changes, regenerative changes, foveolar hyperplasia, and chromic or active inflammation are described. Nishida et al. found no association between the range of atrophic changes and lanthanum depositions. Our patient also showed no atrophic changes in the mucosa, which would be concordant with Nishidas observations. Haratake et al. and Valika et al. found that preformed ulcers as well as underlying pathologies induced by NSARs aggravate the entry of lanthanum.As those mucosal changes are often described with a helicobacter pylori positive gastritis, several authors looked for a relationship between helicobacter infection and lanthanum deposition. Namie et al. suggest that a helicobacter pylori infection may aggravate lanthanum entry through the compromised mucosal barrier. Shitomi et al. did not find helicobacter pylori infection in patients with a lanthanosis and propose that a helicobacter infection might prevent accumulation of lanthanum in the mucosa through a higher pH and a disturbed histiocytic infiltration in the setting of an inflammation. Iwamuro et al. suggest that the gastric body is predominantly affected by lanthanum deposition, which was also true for our patient, because of the prolonged contact time of lanthanum with the mucosa.
Another reason why it is important that endoscopist should know about gastric lanthanosis is that it can endoscopically imitate early gastric cancer. Yabuki et al. even described squamous cell carcinoma associated with lanthanum deposition in a rat model. They also found that other mucosal lesions such as chronic inflammation and intestinal metaplasia were more frequent in mucosa with lanthanum depositions. So, they conclude that lanthanum could indirectly induce metaplasia. Tabushi et al. described the first case of early gastric cancer in association with gastric lanthanosis. Shitomie et al. and Takatsuna et al. described gastric cancer in gastric lanthanosis patients, but they found less or any lanthanum depositions in the neoplasia itself. They suggest that the neoplastic mucosa has a malfunctioning absorption mechanism which leads to lesser lanthanum deposition in that area. With this in mind it is crucial to know how those depositions develop over time and if they are reversible. Lanthanum depositions seem to gradually expand over time, while taking lanthanum carbonate, in humans as well as in a rat model. Whilst Rothenberg et al. observed a reduction in symptoms and histological findings after cessation of lanthanum carbonate, Awad et al. found only a reduction of symptoms. Namie et al. and Hoda et al. described persisting depositions after cessation. Hoda et al. reported one patient that received a kidney transplant and discontinued lanthanum carbonate. What this patient has in common with our patient is the discontinuation of lanthanum carbonate due to kidney transplant and continuing lanthanum deposition in the gastric mucosa. We found no other cases in the literature that described a long cessation of lanthanum carbonate with lanthanum deposits. A limitation of our case report is that we have no preceding endoscopies or biopsies, so we do not know how the lanthanum deposition changed over time. We think that the immunosuppressants our patient takes could be involved in the long duration of the deposition. As Tacrolimus and Mycophenolat inhibit mainly lymphocytes, but also macrophage immune response one could postulate that this leads to a prolonged clearance of lanthanum. But neither the accumulation-, nor the clearance mechanism are understood, so we can only speculate at this moment.