Table 2. targeted Metabolites grouped by airway inflammation phenotypes
in the validation set |
Table 2. targeted Metabolites grouped by airway
inflammation phenotypes in the validation set |
Table 2. targeted
Metabolites grouped by airway inflammation phenotypes in the validation
set |
Table 2. targeted Metabolites grouped by airway inflammation
phenotypes in the validation set |
Table 2. targeted Metabolites grouped
by airway inflammation phenotypes in the validation set |
Table 2.
targeted Metabolites grouped by airway inflammation phenotypes in the
validation set |
Variables |
EA |
NA |
PGA |
F/χ2 |
P
value |
n |
35 |
30 |
49 |
|
|
Diethanolamine, nmol/L |
1.13(0.31, 37.48) |
14.36(0.31, 29.96) |
5.03(0.31, 31.76) |
0.419 |
0.811 |
Histamine, nmol/L |
186.97(49.93, 663.85) |
33.88(9.68, 93.17)a |
118.88(13.54, 263.37)b |
16.174 |
<0.001 |
Creatinine, nmol/L |
364.55(275.61, 503.29) |
418.74(318.41, 730.73) |
368.45(292.09, 623.45) |
3.739 |
0.154 |
Adenine, nmol/L |
158.85(89.21, 251.09) |
130.82(52.38, 262.55) |
198.31(111.25, 350.34) |
3.881 |
0.144 |
Acetylcholine, nmol/L |
0.31(0.31, 187.96) |
23.89(0.31, 112.99) |
0.31(0.31, 64.59) |
2.797 |
0.247 |
Phosphorylcholine, nmol/L |
189.63(110.08, 3201.77) |
1851.12(264.00,
15225.36)b |
438.43(198.54, 26775.05 |
6.037 |
0.049 |
Glycerophosphocholine, nmol/L |
2553.49(682.95, 8122.17) |
716.74(341.96, 2290.81)a |
5114.09(1689.96, 20211.77)b,c |
20.165 |
<0.001 |
Adenosine 5’-monophosphate, nmol/L |
63.01(44.71, 719.82) |
1296.76(92.87, 7312.97)a |
152.13(44.38, 664.24)c |
11.814 |
0.003 |
Pyruvate, nmol/L |
9066.60(5386.23, 14086.09) |
8976.54(5732.44,
13815.05) |
7607.23(4837.88, 12730.67) |
0.327 |
0.849 |
Lactate, nmol/L |
31323.49(11645.66, 70410.53) |
45079.44(29664.26,
99143.60) |
27791.58(13036.10, 61869.96) |
5.307 |
0.070 |
Glyceric acid, nmol/L |
82.31(82.31, 452.54) |
434.50(82.31, 641.01)b |
82.31(82.131, 461.93)d |
6.534 |
0.038 |
3-Hydroxyisovaleric acid, nmol/L |
195.62(59.68, 315.78) |
73.59(42.69,
193.64) |
117.49(64.34, 254.28) |
4.394 |
0.111 |
Taurine, nmol/L |
11941.08(8989.49,15724.86) |
27304.15(17812.74,
49177.67)a |
12408.37(7877.01, 19915.33)c |
28.064 |
<0.001 |
Barbituric acid, nmol/L |
9.15(9.15, 36.34) |
9.15(9.15, 57.99) |
9.15(9.15, 9.15) |
3.698 |
0.157 |
Allantoin, nmol/L |
9948.25(552.17, 29158.91) |
10041.04(5825.87,
14776.30) |
10029.46(4741.30, 23504.00) |
0.051 |
0.975 |
5-L-Glutamyl-L-alanine, nmol/L |
20.72(2.75, 46.35) |
63.63(14.49,
184.20)a |
37.63(14.30, 95.90)b |
10.915 |
0.004 |
Arginyl-Serine, nmol/L |
8.23(8.23, 8.23) |
8.23(8.23, 70.81) |
8.23(8.23, 8.23) |
1.433 |
0.488 |
N-Acetylneuraminic acid, nmol/L |
14613.85(7482.63, 25123.29) |
15285.09(10212.22, 29827.90) |
19793.16(14160.44, 36193.90)b |
7.077 |
0.029 |
Cyclohexylamine, nmol/L |
8.19(5.85, 13.77) |
8.63(3.67, 12.36) |
12.17(8.32, 19.33)b,d |
7.347 |
0.025 |
Nicotinamide, nmol/L |
96.35(65.83, 213.90) |
186.95(68.17, 467.24)b |
178.73(76.51, 328.91)b |
7.383 |
0.025 |
Dihydrothymine, nmol/L |
76.08(63.07, 100.40) |
119.85(87.71, 172.38)a |
99.94(65.00, 141.26)b,d |
14.549 |
0.001 |
L-Leucine, nmol/L |
1301.48(1042.41, 2866.16) |
6101.80(2371.16,
14427.98)a |
2217.51(1575.11, 3415.91)a,c |
22.558 |
<0.001 |
Tyramine, nmol/L |
9.16(8.51, 10.76) |
11.13(9.36, 15.28)a |
9.52(8.58,
11.63)d |
10.445 |
0.005 |
L-Glutamate, nmol/L |
1290.79(943.51, 1532.14) |
2641.40(1279.93,
6459.78)a |
1521.64(868.38, 1970.67)c |
13.690 |
0.001 |
Xanthine, nmol/L |
249.41(160.61, 414.90) |
443.45(247.05, 816.71)a |
266.67(135.92, 575.51) |
7.461 |
0.024 |
L-Phenylalanine, nmol/L |
2232.30(1476.07, 3956.09) |
4312.25(2156.40,
8653.09)a |
3444.02(2327.59, 4802.50)a |
12.856 |
0.002 |
Alanyl-Leucine, nmol/L |
8.46(3.83, 13.41) |
143.98(42.70, 677.71)a |
13.48(6.59, 25.49)b,c |
54.661 |
<0.001 |
Allocystathionine, nmol/L |
2.75(1.48, 3.98) |
4.27(1.50, 6.53) |
2.49(0.95, 5.86) |
3.135 |
0.209 |
Salbutamol, nmol/L |
312.90(141.64, 1060.22) |
331.76(127.14, 974.82) |
365.77(106.66, 1401.31) |
0.069 |
0.966 |
Phenylalanyl-Serine, nmol/L |
4.96(2.50, 7.65) |
29.35(13.33, 71.03)a |
6.48(4.30, 12.89)b,c |
39.718 |
<0.001 |
Threoninyl-Phenylalanine, nmol/L |
26.02(6.84, 45.36) |
158.42(90.13,
429.76)a |
36.52(16.56, 90.06)c |
42.313 |
<0.001 |
Phenylalanylphenylalanine, nmol/L |
35.54(10.67, 85.26) |
92.04(50.64,
190.22)a |
63.79(42.91, 139.07)a |
12.310 |
0.002 |
Indolelactic acid, nmol/L |
2.79(2.79, 7.67) |
6.58(2.79, 15.06) |
4.11(2.79, 12.14) |
3.141 |
0.208 |
Dodecanoic acid, μg/mL |
0.19(0.15, 0.28) |
0.20(0.11, 0.31) |
0.11(0.07, 0.22)a,d |
9.645 |
0.008 |
cis-9-Palmitoleic acid, μg/mL |
3.90(3.02, 6.34) |
4.41(3.24, 6.19) |
3.69(2.77, 5.41) |
1.041 |
0.594 |
Heptadecanoic acid, μg/mL |
1.28(1.01, 1.87) |
1.18(0.93, 1.67) |
1.59(1.22, 2.40)b,c |
9.641 |
0.008 |
Stearic acid, μg/mL |
30.80(20.19, 40.30) |
33.17(19.88, 51.15) |
23.59(16.50, 44.16) |
2.101 |
0.350 |
Oleic acid, μg/mL |
24.43(13.53, 44.19) |
27.60(14.44, 50.94) |
40.75(24.93, 88.11)a,d |
8.847 |
0.012 |
Linoleic acid, μg/mL |
4.73(2.34, 8.68) |
5.25(2.30, 10.61) |
6.99(4.80,
14.13)a |
7.356 |
0.025 |
EA, eosinophilic asthma; NA, neutrophilic asthma; PGA, paucigranulocytic
asthma;
Vs. EA, aP < 0.01,
bP < 0.05; Vs. NA,
cP < 0.01, ,
dP < 0.05
|
EA, eosinophilic asthma; NA, neutrophilic asthma; PGA, paucigranulocytic
asthma;
Vs. EA, aP < 0.01,
bP < 0.05; Vs. NA,
cP < 0.01, ,
dP < 0.05
|
EA, eosinophilic asthma; NA, neutrophilic asthma; PGA, paucigranulocytic
asthma;
Vs. EA, aP < 0.01,
bP < 0.05; Vs. NA,
cP < 0.01, ,
dP < 0.05
|
EA, eosinophilic asthma; NA, neutrophilic asthma; PGA, paucigranulocytic
asthma;
Vs. EA, aP < 0.01,
bP < 0.05; Vs. NA,
cP < 0.01, ,
dP < 0.05
|
EA, eosinophilic asthma; NA, neutrophilic asthma; PGA, paucigranulocytic
asthma;
Vs. EA, aP < 0.01,
bP < 0.05; Vs. NA,
cP < 0.01, ,
dP < 0.05
|
EA, eosinophilic asthma; NA, neutrophilic asthma; PGA, paucigranulocytic
asthma;
Vs. EA, aP < 0.01,
bP < 0.05; Vs. NA,
cP < 0.01, ,
dP < 0.05
|