Correlations of differential metabolites with clinical and
inflammatory profiles in the validation set
Correlations analysis showed that differentially expressed metabolites
correlated to lung function, asthma control and inflammatory profiles in
all subjects with asthma (Figure 3 and Table E5) with the detail in the
Online Data Supplement.
We explored the association between metabolites and severe asthma
exacerbation during the 12 month follow-up using logistic regression and
negative binomial regression models (Table E6). As a result, adenosine
5’-monophosphate was significantly associated with severe asthma
exacerbation (Table 3). Adenosine 5’-monophosphate had increased rate
ratios of proportions of patients experiencing severe asthma
exacerbation (RRadj = 1.000, 95%CI = [1.000, 1.000], P =
0.050) and had increased rate ratios of severe asthma exacerbation times
(RRadj = 1.000, 95%CI = [1.000, 1.000], P = 0.008) after
adjusting for age, gender, BMI and FEV1%. In addition,
allantoin and nicotinamide both had increased rate ratios of severe
asthma exacerbation times (RRadj = 1.000, 95%CI = [1.000, 1.000],P = 0.043, and RRadj = 1.001, 95%CI = [1.000, 1.002],P = 0.021, respectively)