Correlations of differential metabolites with clinical and inflammatory profiles in the validation set
Correlations analysis showed that differentially expressed metabolites correlated to lung function, asthma control and inflammatory profiles in all subjects with asthma (Figure 3 and Table E5) with the detail in the Online Data Supplement.
We explored the association between metabolites and severe asthma exacerbation during the 12 month follow-up using logistic regression and negative binomial regression models (Table E6). As a result, adenosine 5’-monophosphate was significantly associated with severe asthma exacerbation (Table 3). Adenosine 5’-monophosphate had increased rate ratios of proportions of patients experiencing severe asthma exacerbation (RRadj = 1.000, 95%CI = [1.000, 1.000], P = 0.050) and had increased rate ratios of severe asthma exacerbation times (RRadj = 1.000, 95%CI = [1.000, 1.000], P = 0.008) after adjusting for age, gender, BMI and FEV1%. In addition, allantoin and nicotinamide both had increased rate ratios of severe asthma exacerbation times (RRadj = 1.000, 95%CI = [1.000, 1.000],P = 0.043, and RRadj = 1.001, 95%CI = [1.000, 1.002],P = 0.021, respectively)