Statistical analysis
The chi-square test for trend was used to compare the distribution of the prevalence of various factors at each of the yearly visits. The Kaplan-Meier method was applied to estimate the probability of asthma onset, and the log-rank test was used to compare the probability between AR phenotypes. All reported P values are 2-tailed, with a P value of <.05 considered to be statistically significant. Statistical analyses were performed with GraphPad Prism 8 (GraphPad Software; La Jolla, California) and SPSS (version 26; SPSS; Chicago, Illinois).