Supporting Information

Figure S1. Vaccinated goats were exposed to mosquitoes.
Figure S2. Depth of coverage across DDVax segments. Coverage depth was tabulated using samtools and depth in 10 nt windows is plotted.
Figure S3. Detection of DDVax viral RNA following exposure to limiting dilutions of virus at 14 dpi.
Figure S4. Viral RNA detected in goat blood at 1, 2, 3 days post-vaccination.
Figure S5. Mosquito cell culture shows reduced efficiency of viral replication for DDVax.
Table S1. RNA positive RVFV-exposed samples from in vitromosquito challenge.
Table S2. RNA positive RVFV DDVax-exposed samples from virus serial dilution experiment.
Table S3. Proportion of mosquitoes with viral CPE in bodies at 7 days post-goat-exposure.