Genetic risk score–predicted risks
Figure 2 displays the inherited susceptibility of each risk factor on
asthma from representative GRSs. We demonstrated the predicted
prevalence of asthma for the three risk factors (obesity, SDB, and sleep
quality) corresponding to the mean GRS in each quintile. All three
factors exhibited an increasing trend of predicted prevalence of asthma
following the increase in quintile. To illustrate, the predicted
prevalence of asthma was 6% for those whose GRS for SDB and sleep
quality was in the lowest 20% of the sample (Q1) compared with 13% for
those whose GRS was in the highest 20% (Q5). However, obesity revealed
a less prominent increase. The predicted prevalence of asthma for those
whose GRS for obesity in Q1 was 7%, with an increasing trend to 11%
for those with scores in Q5.