Correspondence and requests for reprints should be addressed to
Yungling Leo Lee, MD, PhD
Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 11529, Taiwan
Tel: +886-2-2652-3013
E-mail:leolee@ibms.sinica.edu.tw
Conflicts of interest: The authors declare no conflict of interest.
Financial disclosure: This work was supported by the National Health Research Institutes of Taiwan [NHRI-EX110-10718PC and NHRI-EX109-10606PI]. National Health Research Institutes supported genomic study expenditures in this study.
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Abbreviations : BMI, body mass index; CI, confidence interval; DTHM, discrete-time hazard model; FeNO, fractional exhaled nitric oxide; FEV1/FVC, forced expiratory volume in 1 second/forced vital capacity; IV, instrumental variable; MR, Mendelian randomization; OR, odds ratio; GRS, genetic risk score; SDB, sleep-disordered breathing; SNP, single-nucleotide polymorphism; TCHS, Taiwan Children Health Study; 2SLS, two-stage least square
Author contributions: Dr. Yang-Ching Chen contributed to data collection, hypothesis generation, data interpretation, and writing the manuscript. Prof. Yungling Lee reviewed the study design and data collection and interpretation, supervised the study, and critically revised the manuscript for essential intellectual content. Dr. Ming-Wei Su and Prof. Ben Brumpton assisted in a critical part of statistical analysis and the manuscript review. All the authors approved the final manuscript for submission and publication and agreed to be accountable for all aspects of the work.