Correspondence and requests for reprints should be addressed to
Yungling Leo Lee, MD, PhD
Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road,
Sec. 2, Taipei 11529, Taiwan
Tel: +886-2-2652-3013
E-mail:leolee@ibms.sinica.edu.tw
Conflicts of interest: The authors declare no conflict of
interest.
Financial disclosure: This work was supported by the National
Health Research Institutes of Taiwan [NHRI-EX110-10718PC and
NHRI-EX109-10606PI].
National Health Research Institutes supported genomic study expenditures
in this study.
Word count: 227 for abstract; 2810 for text.
Abbreviations : BMI, body mass index; CI, confidence interval;
DTHM, discrete-time hazard model; FeNO, fractional
exhaled nitric oxide; FEV1/FVC, forced expiratory volume in 1
second/forced vital capacity; IV, instrumental variable; MR, Mendelian
randomization; OR, odds ratio; GRS, genetic risk score; SDB,
sleep-disordered breathing; SNP, single-nucleotide polymorphism; TCHS,
Taiwan Children Health Study; 2SLS, two-stage least square
Author contributions: Dr. Yang-Ching Chen contributed to data
collection, hypothesis generation, data interpretation, and writing the
manuscript. Prof. Yungling Lee reviewed the study design and data
collection and interpretation, supervised the study, and critically
revised the manuscript for essential intellectual content. Dr. Ming-Wei
Su and Prof. Ben Brumpton assisted in a critical part of statistical
analysis and the manuscript review. All the authors approved the final
manuscript for submission and publication and agreed to be accountable
for all aspects of the work.