Risk factors
Category
Physician-diagnosed asthma Physician-diagnosed asthma Physician-diagnosed asthma
FEV1/FVC (%)
FEV1/FVC (%)
FEV1/FVC (%)
OR 95% CI 95% CI β 95% CI 95% CI
Obesity Observational 1.26 1.07 1.47 −1.16 −1.37 −0.95
(28 SNPs, F = 80.60) MR 2SLS 1.08 1.00 1.16 −2.44 −4.24 −0.65
Physical activity Observational 1.01 1.00 1.01 −0.09 −0.24 0.06
(15 SNPs, F = 18.62) MR 2SLS 0.91 0.82 1.00 0.77 −1.39 2.93
Cardiopulmonary physical fitness Observational 0.99 0.98 1.01 0.74 0.37 1.11
(13 SNPs, F = 11.68) MR 2SLS 0.88 0.69 1.13 4.92 −0.27 10.1
Sleep-disordered breathing Observational 1.60 1.36 1.88 0.09 −0.27 0.45
(14 SNPs, F = 10.27) MR 2SLS 1.26 1.00 1.58 6.40 1.15 11.7
Sleep quality Observational 1.01 1.00 1.01 −0.13 −0.29 0.03
(15 SNPs, F = 7.09) MR 2SLS 1.42 1.06 1.92 0.94 −4.82 6.70