CONCLUSION
We found that obesity, SDB, and sleep quality were consistently
associated with asthma in observational, MR, and prospective survival
analysis models. After a series of complementary analyses to further
strengthen the causal inference, poor sleep quality and SDB emerged as
the most plausible causal risk factor, followed by obesity. Hence,
lifestyle interventions aimed at promoting high-quality sleep and
reducing SDB symptoms, such as weight management, might effectively
reduce asthma risk.