Figure 4. Mediation proportions (%) as calculated in the
observational and Mendelian Randomization analyses
Footnotes of Figure 4: The proportion of mediation indicates
the proportion of indirect mediation effect to total effect from obesity
to asthma. Mediation proportion of the observational models were
calculated by single-mediator analysis. Mediation proportion of the MR
models were calculated according to equations by Burgess et al.Observational models were adjusted by age, sex, parental education, and
household environmental tobacco smoking. Definition of
abbreviations: BMI=body mass index; FeNO=fractional
exhaled nitric oxide; FEV1/FVC = forced expiratory volume in 1 s/forced
vital capacity