Correspondence and page proofs should be sent to:
Yungling Leo Lee, MD, PhD
Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 11529, Taiwan
Tel: +886-2-2652-3013
E-mail: leolee@ibms.sinica.edu.tw
Financial disclosure: This work was supported by the National Health Research Institutes of Taiwan [NHRI-EX110-10718PC and NHRI-EX109-10606PI].
Conflicts of interest: The authors declare no conflict of interest.
Author contributions: Dr. Yang-Ching Chen collected the cohort data, interpreted the data, and wrote the manuscript. Prof. Yen-Tsung Huang and Prof. Wen-Harn Pan assisted in the critical part of the statistical analysis, interpreted data, and revised it critically for crucial intellectual content. Prof. Yungling Lee reviewed the study design, collected data, interpreted data, supervised the study, and revised the manuscript critically for valuable intellectual content. All authors approved the final manuscript as submitted and published and agree to be accountable for all aspects of the work.
Word count: 250 for abstract; 3000 for text.