1.1 Study Population
We enrolled 23 consecutive children, aged 0-18 years, with type1 or 2
SMA, regularly followed at our Unit. The study is part of a larger
natural history study on SMA approved by the Ethics Committee of our
Institution, and a fully informed consent from the parents of each
participant was obtained before the study.
For all the participating families, information on type of SMA, degree
of neuroscoliosis/chest deformities, type of treatment, number of
previous lung infections/ICU admissions, type of ventilation
(non-invasive vs mechanical vs spontaneous breathing) were collected in
a dedicated form.