1Additionally adjusted for body mass index, estimated
creatinine clearance and donors’ ABCC2 1249 G>Agenotype.
AUCt,ss – area under the concentration-time curve
during dosing interval at steady-state; Cmax,ss – peak
plasma concentration at steady-state; C0 – morning
pre-dose trough; C12 – evening trough;
CLT/Fss – apparent total body clearance at steady-state