N |
|
12 |
|
56 |
Men |
|
6 (50.0) |
|
30 (53.6) |
Age (years) |
|
46.5±13.3 (26-68) |
|
50.5±12.8 (16-71) |
Body mass index (kg/m2) |
|
24.9±6.3 (17.7-39.5) |
|
24.0±3.3 (14.5-30.4) |
Mycophenolate mofetil |
|
2 (16.7) |
|
21 (37.5) |
1000 mg bid
|
|
1
|
|
17
|
750 mg bid
|
|
0
|
|
2
|
500 mg bid
|
|
1
|
|
2
|
Enteric coated mycophenolate |
|
10 (83.3) |
|
35 (62.5) |
Daily dose (mg)
|
|
All 720 mg bid
|
|
All 720 mg bid
|
Cyclosporine A |
|
6 (50.0) |
|
37 (66.1) |
Morning dose (mg/kg)
|
|
160 (144-175; 125-175)
|
|
150 (125-188; 75-250)
|
Evening dose (mg/kg)
|
|
162 (125-181; 125-200)
|
|
150 (125-200; 75-250)
|
Morning trough (µg/L)
|
|
212±53 (169-311)
|
|
204±64 (70-341)
|
Tacrolimus |
|
6 (50.0) |
|
19 (33.9) |
Morning dose (mg)
|
|
2.0 (1.7-3.9; 1.0-5.0)
|
|
3.0 (2.5-3.0; 1.5-4.0)
|
Evening dose (mg)
|
|
3.3 (2.2-4.3; 1.5-5.0)
|
|
3.0 (3.0-4.0; 2.0-4.0)
|
Morning trough (µg/L)
|
|
11.0±3.2 (7.8-16.9)
|
|
10.8±5.8 (3.4-27.4)
|
Prednisone equivalent (mg/day) |
|
40 (30-40; 30-60) |
|
35 (30-47;
20-75) |
Urine output (L/day) |
|
2.4 (2.1-2.6; 1.8-4.3) |
|
2.6 (2.1-3.2;
1.1-5.7) |
Estimated creatinine clearance (mL/min) |
|
45±16 (29-84) |
|
41±11
(23-74) |
CYP3A4*22 genotype |
|
|
|
|
*1/*1
|
|
12 (100)
|
|
55 (98.2)
|
*1/*22
|
|
0
|
|
1 (1.8)
|
CYP3A5*3 genotype |
|
|
|
|
*3/*3
|
|
11 (91.7)
|
|
48 (85.7)
|
*1/*3
|
|
1 (8.3)
|
|
8 (14.3)
|
UGT2B7 -161C>T genotype |
|
|
|
|
Variant allele
|
|
9 (75.0)
|
|
47 (83.9)
|
Wild type
|
|
3 (25.0)
|
|
9 (16.1)
|
UGT1A9 -275 / -2152 diplotype |
|
|
|
|
Variant allele
|
|
0
|
|
3 (5.4)
|
Wild type
|
|
12 (100)
|
|
53 (94.6)
|
ABCB1 2677 / 3435 / 1236 diplotype |
|
|
|
|
Wild type or 1 variant allele
|
|
3 (25.0)
|
|
15 (26.8)
|
2-3 variant alleles
|
|
6 (50.0)
|
|
25 (44.6)
|
4-6 variant alleles
|
|
3 (25.0)
|
|
16 (28.6)
|
SLC01B1 521T>C genotype |
|
|
|
|
Variant allele
|
|
4 (33.3)
|
|
21 (37.5)
|
Wild type
|
|
8 (66.7)
|
|
35 (62.5)
|
ABCC2 -24 C>T genotype |
|
|
|
|
Variant allele
|
|
2 (16.7)
|
|
19 (33.9)
|
Wild type
|
|
10 (83.3)
|
|
37 (66.1)
|
ABCC2 1249 G>A genotype |
|
|
|
|
Variant allele
|
|
4 (33.3)
|
|
23 (41.1)
|
Wild type
|
|
8 (66.7)
|
|
33 (58.9)
|
Donor’s ABCC2 1249 G>A genotype |
|
|
|
|
Variant allele
|
|
6 (50.0)
|
|
21 (37.5)
|
Wild type
|
|
6 (50.0)
|
|
35 (62.5)
|