No Clinical and Gross lesions Clinical signs (%) (n=66) Clinical signs (%) (n=66) Major histological changes (%) (n=66)
1 Lacrimation and nasal discharge 34 (51.5) 34 (51.5) Hyperkeratosis  46 (69.7)
2 Fever, inappetence and reduced milk yield 41 (62.1) 41 (62.1) Diffuse granulomatous reaction in dermis and epidermis 39 (59.1)
3 Superficial lymph node enlargement 19 (28.7) 19 (28.7) Vasculitis and lymphangitis 39 (59.1)
4 Leg edema and pustular lesions in feet with lameness 10 ((15.1) 10 ((15.1) Spongiosis  34 (51.5)
5 Localized skin/subcutaneous nodules 20 (30.3) 20 (30.3) Vacuolar degeneration of epithelial cells 15 (22.7)
6 Diffuse/generalized skin/subcutaneous nodules and papules all over the body 46 (69.7) 46 (69.7) Acanthosis (pigment or hemosiderin deposition)  12 (18.0)
7 Infarction and coagulative necrosis in the dermis  10 (15.1)
8 Intracytoplasmic eosinophilic viral inclusions in keratinocytes. 2 (3.03)