Colorectal cancer |
Interference with the nuclear β-catenin-Bcl9-LEF/TCF
triple-complex and up-regulation of c-jun leading to reduced Wnt
activity |
Inhibitory effect on CRC development |
Monin et al.
(2016) |
|
Co-localization of Frizzled 1 or β-catenin with LC3, (an autophagosome
marker), inhibition of mTORC1 and ULK1 |
Suppression of CRC via
autophagy |
J. Wang et al. (2019) |
|
Downregulation of Notch signalling and upregulation of tumour
suppressor microRNAs (miR-200) |
Suppression of growth and migration of
colon cancer cells, and induction of cell apoptosis |
Suliman et al.
(2016) |
|
Inhibition of the STAT-3 pathway via down-regulation of survivin and
cyclin-D1 |
Induction of cell apoptosis and cell cycle arrest |
M. M. Wu
et al. (2020) |
Lung cancer |
Caspase‐3 activation and decreased expression level of
c‐myc protein |
Synergistic effect in cisplatin-resistant cells and
induction of apoptosis |
Zuo et al. (2018) |
|
Blockage of p-STAT-3 binding to the PD-L1 promoter leading to T-cell
mediated cell lysis |
Delayed tumour growth in presence of PD-L1
antibody |
Luo et al. (2019) |
|
Inhibition of S100A4, reduced NF-κB-mediated MMP-9 expression |
Reduction in proliferation and invasion of cells |
Stewart et al.
(2016) |
Breast cancer |
Inhibition of IL-6/STAT-3 and down-regulation of TWIST
and SNAIL |
Inhibition of adipocyte induced epithelial mesenchymal
transition leading to decreased proliferation, migration and invasion of
human breast cancer cell lines and induction of apoptosis |
Gyamfi, Lee,
Min, and Choi (2019) |
|
Activation of caspase-3 and down-regulation of Bcl-2, Mcl-1 and
Survivin |
Growth inhibition of breast cancer cell lines and induction
of apoptosis |
Ye et al. (2014) |
Head and neck cancer |
Inhibition of STAT-3 |
Apoptosis in tumour cells
and growth suppression. Synergistic effect with EGFR inhibition |
R. Li
et al. (2013) |
|
Increased let-7d expression and decreased CDC34 expression |
G1 arrest
in squamous cell carcinoma cell lines and inhibition of xenograft growth |
Han et al. (2018) |
|
Down-regulation of VEGFA, MMP2, ROCK1 and CdC42. Downregulation of
phophorylated STAT-3 expression and upregulation of miR-124 |
Inhibition
of proliferation, promotion of apoptosis, inhibition of vasculogenic
mimicry in vitro and in vivo
|
X. Li et al.
(2018) |
|
Inhibition of Wnt/β-catenin signaling pathway, downregulation of
glycogen synthase kinase-3β and cyclin D1 |
Reduced formation of primary
and secondary tumorspheres and inhibition of EMT in oral squamous cell
carcinoma cells |
L. H. Wang, Xu, Fu, Chen, and Yang
(2018) |
Ovarian Cancer |
Decreased expression of p-STAT-3, inactivation of
MEK1/2-ERK1/2 pathways, and decreased mitochondrial respiration and
aerobic glycolysis |
Suppression of ovarian carcinoma growth and
induction of cell apoptosis |
Shangguan et al. (2020) |
|
Decreased expression of proteins in the Wnt/β-catenin, mTOR and STAT-3
pathways and preferential targeting of CD133 |
Inhibition of
chemo-resistant ovarian cancer cells |
Arend et al.
(2016) |
|
Inhibition of Wnt/β-catenin pathway |
Decreased cellular proliferation
and increased cell death |
Arend et al. (2014) |
Glioblastoma Multiforme |
Inhibition of WNT, NOTCH, mTOR and NF-κB
signaling cascades |
Cytostatic, cytotoxic and anti-migratory effect on
human Glioblastoma cell lines and dimunition of its malignant potential
in vivo |
Wieland et al. (2013) |
|
Down-regulation of Wnt/β-catenin, PI3K/AKT, MAP kinase and STAT-3 |
Increase in protein ubiquitination and autophagy, leading to induction
of toxicity in human glioblastoma cells |
Cheng, Morales, Zhang, Mito,
and Tsin (2017) |
Hepatocellular Carcinoma |
Down-regulation of expression of cyclin D1
and MMP-9 |
Suppressed proliferation and migration of HCC cells lines |
Tomizawa et al. (2015) |
|
Down-regulation of cyclin D1 via a down-regulation of the Wnt-3
pathway |
Suppressed proliferation of HCC cells by induction of
apoptosis |
Tomizawa et al. (2013) |
|
Inhibition of STAT-3 and more downstream anti-apoptotic proteins |
Suppressed cell viability and inhibited clone formation in HCC cells and
synergism with cisplatin by promotion of apoptosis |
C. Wang et al.
(2018) |
|
Reduced expression of proteins in the Wnt-β- catenin, STAT-3, AKT-mTOR
and epidermal growth factor signalling pathways |
Increased expression
of 20 genes that are down-regulated and reduced expression of 29 genes
that are up-regulated in the 274-gene HCC signature |
B. Chen et al.
(2017) |
Leukaemia |
Increased levels of reactive oxygen species, inhibition of
glutathione synthesis and NFAT signalling |
Anti-tumor activity seen
against drug-resistant leukaemia cells |
Hamdoun, Jung, and Efferth
(2017) |
|
Inhibition of NF-κB |
Synergism with frontline chemotherapeutic agents
in killing acute myeloid leukaemia cells |
Y. Jin et al.
(2010) |
Prostate Cancer |
Inhibition of STAT-3 phosphorylation via IL-6 pathway |
Induction of apoptosis and inhibition of cell growth and cell
migration in enzulatamide resistant prostate cancer cells |
Liu et al.
(2015) |
|
Inhibition of androgen receptor variant 7 |
Reversal of enzulatamide
and bicalutamide resistance in castrate resistant prostate cancer cells |
Liu et al. (2017) |