Main results
A significantly lower first pregnancy live birth rate (FPLBR) was found
in carriers than in noncarriers with RPL (OR: 0.55; 95% CI: 0.46-0.65;
p<0.00001). Regarding FPLBR between translocation or inversion
carriers and noncarriers, a markedly decreased FPLBR was found in
translocation (OR: 0.44; 95% CI: 0.31–0.61; p<0.00001) but
not inversion carriers. The accumulated live birth rate (ALBR) (OR:
0.96; 95% CI: 0.90–1.03; p=0.26) was similar, while the miscarriage
rate (MR) of accumulated pregnancies (OR: 2.21; 95% CI: 1.69–2.89;
p<0.00001) was significantly higher in the carriers than in
noncarriers with RPL. The ALBR was not significant (OR: 1.82; 95% CI:
0.38–8.71; p=0.45) but the MR (OR: 5.75; 95% CI: 2.57–12.86;
p<0.0001) was markedly lower for carriers who choose PGD than
natural conception.