Adrenal insufficiency
Adrenal insufficiency (AI) is characterized by insufficient glucocorticoid and mineralocorticoid secretion and requires replacement therapy with hydrocortisone and fludrocortisone. Several reviews concluded that AI patients exhibited impaired physical and mental health as well as increased psychopathology independent of the aetiology of AI (Hahner et al. , 2021). Importantly, several studies have shown that psychopathology, cognition, and quality of life depend on hydrocortisone treatment regimens that closely mimic physiological cortisol secretion and on sufficient MR activation through fludrocortisone (Øksnes et al. , 2014; Schultebraucks K, Wingenfeld K, Otte C, 2016). The (interdependent) contributions of MR and GR to these psychopathological symptoms remain however undefined.