Mineralocorticoid receptors in major depressive disorder (MDD)
and borderline personality disorder (BPD).
Several mental disorders are characterized by HPA axis dysfunction. In
this review, we specifically focus on MDD and BPD as two examples of
stress-associated disorders. Historically, research on corticoid
receptor function in mental disorders is predominantly focused on GR
alterations (Binder et al. , 2004; Martín-Blanco et al. ,
2014). However, variations in the MR gene are commonly associated with
negative memory bias, amygdala reactivity, and life adversity in mental
disorders (Bogdan, Williamson and Hariri, 2012; Vogel et al. ,
2016; Vinkers et al. , 2015) and altered aldosterone
concentrations have been repeatedly found in MDD (Murck H, Büttner M,
Kircher T, 2014; Nowacki, Wingenfeld, Kaczmarczyk, Chae, Salchow,et al. , 2020). Therefore, an association of the MR function with
cognitive and emotional dysfunction is plausible.