Fig. 1 | The reopening of “CANCER MOONSHOT”:
From cancer oppression to conquer cancer . It’s believed that with the
help of iRT-ABCDEFG program which includes the Goal of combating cancer
in the globe, people will get the final victory by development of fresh
preventive strategies, new diagnostic tools, and novel therapies of
precise medicine.
During the pandemic or post-Covid-19 era, patients with active cancer
and in cancer survivors have a worse outcome due to persistent
multi-organ viral attacks or an abnormal immune
response14. There are both more adverse cardiac
outcomes and significantly increased cardiac biomarkers as well as a
high in-hospital mortality in Covid-19 patients with
cancer15 due to mainly driven by gender, advancing
age, smoking, socioeconomic deprivation, and other
comorbidities16,17, such as cardiovascular disease
(CVD), diabetes. And these risk factors are more strongly associated
with infection death. Covid-19 cases with both cancer and established
CVD and risk factors are at the highest risk for serious complications,
including death, thus, these patients need to be screened by both
cardiac biomarkers and a more focused cardiovascular imaging approach so
as to minimize the risk of SARS-CoV-2 infection18. In
fact, Covid-19 is a vital risk factor for acute myocardial infarction
and ischaemic stroke in the era of Covid-1919.
Normalized understanding, lung cancer is still the leading cause of
cancer death in the US (approximately 350 deaths per
day)6, however, breast cancer surpassed lung cancer as
the leading cause of cancer death among Black women in
201920, and the number of cancer survivors continues
to increase mainly due to improvement and advances in early screening,
detection, and targeted treatment6,21. During the
pandemic and post-Covid-19 era, there are rising needs for the rapid
expansion of telemedicine platforms14 for cancer
cases. In a word, patients with cancer need the best possible care
during the COVID-19 pandemic.
A study showed that endotheliopathy presented in Covid-19 is associated
with critical illness and death22. Single-cell atlases
revealed the biological effect of severe SARS-CoV-2 infection and new
cellular targets for treatments23. Genome-wide CRISPR
Screens also show potential therapeutic targets and small-molecule
antagonists may inhibit SARS-CoV-2 infection24. These
studies on the mechanisms and novel treatments will help to combat
Covid-19 for improvement of cancer outcomes. And these new strategies
will help to further improve quality of life (QOL) and outcomes in
cancer patients with Covid-19 in the globe.