Correspondence
Title: An oversight regarding the Club cell?
To the Editor,
I was surprised to a see a title including the outdated term “Clara
Cell” protein, in reference to CC16, in the title and body of the
article by Rallis et al recently published in Pediatric Pulmonology (1).
It appears that there needs to be an ongoing reminder that due to the
association of Dr. Max Clara with the Third Reich and his unethical
medical research practices which lead to the identification of this cell
type (2-4) that his name was removed in 2013.
In 2012, Editorial boards of American Thoracic Society, the European
Respiratory Society and the American College of Chest Physicians, based
on recommendations from an expert panel assembled by the Forum of
International Respiratory Societies, agreed to convert to use of the
terms “club cell (Clara)” and “club cell secretory protein (Clara),
and after January 1, 2013, completely transitioning out the use of the
(Clara) eponym.
In our day, where cancel culture is so predominant, questions have been
raised about what lessons are lost when history is erased. Assuming an
oversight was made by the authors, editors and reviewers in not
utilizing the now accepted terms “Club cell secretory protein” or
bronchiolar exocrine cells, it would only be acceptable to mention the
prior term in the setting of an asterisked description explaining the
context and involvement of concentration camp prisoners and their
association with the prior eponym, for educational purposes.
- Rallis D, Baltogianni M, Dermitzaki N, Balomenou F, Papastergiou E,
Maragoudaki E, Tsabouri S, Makis A, Giapros V. Clara cell protein
expression amongst infants with respiratory distress syndrome. Pediatr
Pulmonol. 2022 Mar 18.
- Woywodt A, Lefrak S, Matteson E. Tainted eponyms in medicine: the
”Clara” cell joins the list. Eur Respir J. 2010 Oct;36(4):706-8
- Winkelmann A, Noack T. The Clara cell: a ”Third Reich eponym”? Eur
Respir J. 2010 Oct;36(4):722-7.
- Irwin RS, Augustyn N, French CT, Rice J, Tedeschi V, Welch SJ;
Editorial Leadership Team. Spread the word about the journal in 2013:
from citation manipulation to invalidation of patient-reported
outcomes measures to renaming the Clara cell to new journal features.
Chest. 2013 Jan;143(1):1-4.