Key points
- NOE is a rare but life-threatening condition. Treatment is long-term
intravenous antibiotics. However, there is no evidence on the
complications of antimicrobial treatment in this complex cohort of
patients
- In our study, patients on average are initiated on two different
antibiotic regimes
- 63% of these changes in regimen are due to direct adverse effects
from treatment including drug intolerance and lack of significant
clinical response leading to deterioration and morbid complications
- This novel data provides information clinicians can use when
initiating treatment for NOE and counsel patients appropriately
- The increasing incidence of NOE with an ageing population and the rise
in antibiotic resistances will likely further complicate management of
this condition and prolong treatment duration