Total Intervention Control P-value Relative Risk (95% CI)
Primary outcome
Cumulative AD at 12 months 103/257 (40.1%) 39/119 (32.8%) 64/138 (46.4%) 0.036 0.707 (0.516, 0.967)
Secondary outcomes
AD at 12 months
AD according to the UK Working Party Diagnostic Criteria
76/253 (30%)
24/117 (20.5%)
52/136 (38.2%)
0.003
0.536 (0.354, 0.813)
AD at 6 months
AD according to the UK Working Party Diagnostic Criteria
71/260 (27.3%)
22/120 (18.3%)
49/140 (35.0%)
0.004
0.524 (0.337, 0.813)
Cumulative AD 73/260 (28.1%) 22/120 (18.3%) 51/140 (36.4%) 0.002 0.503 (0.325, 0.779)