Key Results
Lancemaside A (LA), a triterpenoid saponin isolated from CL, impeded the
endosomal entry pathway of SARS-CoV-2 and its variants including Alpha,
Beta, Delta, and Omicron with similar IC50 values of
2.23 ~ 3.37 μM as well as the TMPRSS2-mediated viral
entry pathway with IC50 value of 3.92 μM. LA was also
able to prevent the formation of S-induced multinucleated syncytia.
Mechanically, LA altered the distribution of host cell membrane
cholesterol and blocked the membrane fusion between SARS-CoV-2 and host
cells.