Abbreviations:
AC, Adjudication Committee; ADA, anti-drug antibodies; AUC, area under
the concentration-time curve; CI, confidence interval; CL, clearance;
CWRES, conditionally weighted residual over time; IPRED, individual
predictions; LLOQ, lower limit of quantitation; NMOSD, neuromyelitis
optica spectrum disorder; OLP, open-label period; PK,
pharmacokinetic(s); PD, pharmacodynamic(s); PRED, population
predictions; RCP, randomized control period