Abbreviations:
AC, Adjudication Committee; ADA, anti-drug antibodies; AUC, area under the concentration-time curve; CI, confidence interval; CL, clearance; CWRES, conditionally weighted residual over time; IPRED, individual predictions; LLOQ, lower limit of quantitation; NMOSD, neuromyelitis optica spectrum disorder; OLP, open-label period; PK, pharmacokinetic(s); PD, pharmacodynamic(s); PRED, population predictions; RCP, randomized control period