Drugs
λ-carrageenan was purchased from Sigma-Aldrich, France. CFA consisted ofMycobacterium butyricum (Difco Laboratories, Detroit, USA) dissolved in paraffin oil and saline (0.9% NaCl). The solution was autoclaved for 20 min at 120°C. TTA-A2 (Alomone labs, Jerusalem, Israel) was dissolved in DMSO/Tween80/saline (1:1:8) and orally administered at 1 mg/kg (10 ml/kg). ABT-639 was purchased from CliniSciences (Nanterre, France), dissolved in DMSO/saline (1:9) and injected either intraperitoneally (10, 30, 100 mg/kg, 10 ml/kg) or subcutaneously in the hind paw (2.5 µg in 20 µl) or intrathecally (10 µg in 5 µl).