Index hospitalization complications and mortality:
The overall rate of complications was higher in women than men (8.6% vs. 6.6%, P<0.001). After adjusting of baseline variables using propensity-matched multivariate logistic regression analysis, we found complications were primarily driven by bleeding-related complications, i.e., Major bleed (OR: 1.32 95% CI: 1.03-1.69, p=0.029), blood transfusion (OR: 1.45, 95% CI: 1.06-1.97, p=0.019) and cardiac tamponade (OR: 1.80, 95% CI: 1.13-2.89, p=0.014). Women were more likely to have a peri-procedural ischemic stroke (OR: 2.03, 95% CI:1.01-4.10, p=0.049). On propensity-matched multivariate logistic regression analysis, we found no statistically significant difference in peri-procedural mortality between women and men (OR: 1.88, 95% CI: 0.74-4.79, p=0.185). (Table-2) Mean length of stay (LOS) was longer in women (women:1.4 ± 2.4 days vs. men:1.3 ± 1.8 days, p<0.001). Women were more likely to be discharged to skilled nursing facilities (SNF) (women:3.4% vs. men:1.9%, p<0.001).