Results
Fifty-two children with cold urticaria were recruited, 51.9% were
female and the median age of symptom onset was 9.5 years. Most patients
were managed with second generation H1-antihistamines (sgAHs).
Well-controlled disease on sgAHs was negatively associated with
concomitant CSU (adjusted odds ratio (aOR)=0.69 [95%CI: 0.53,
0.92]). Elevated eosinophils were associated with cold-induced
anaphylaxis (coldA) (aOR=1.38 [95%CI: 1.04, 1.83]), which occurred
in 17.3% of patients. The resolution rate of coldU was 4.8 per 100
patient-years, which was lower than that of CSU (adjusted hazard
ratio=0.43 [95%CI: 0.21, 0.89],
P<10-2).