loading page

Remdesivir: A critical review
  • +7
  • Zeinab Mohseni Afshar,
  • Dariush Hosseinzadeh,
  • Rezvan Hosseinzadeh,
  • Arefeh Babazadeh,
  • Amirreza Allahgholipour, ,
  • Terence Sio,
  • Mark Sullman,
  • Kristin Carson-Chahhoud,
  • Mohammad Barary,
  • Soheil Ebrahimpour
Zeinab Mohseni Afshar
Kermanshah University of Medical Sciences
Author Profile
Dariush Hosseinzadeh
Nacional'nij medicnij universitet imeni O O Bohomol'ca
Author Profile
Rezvan Hosseinzadeh
Babol University of Medical Science
Author Profile
Arefeh Babazadeh
Babol University of Medical Science
Author Profile
Amirreza Allahgholipour,
Tehran University of Medical Sciences
Author Profile
Terence Sio
Mayo Clinic Arizona
Author Profile
Mark Sullman
University of Nicosia
Author Profile
Kristin Carson-Chahhoud
University of South Australia
Author Profile
Mohammad Barary
Babol University of Medical Science
Author Profile
Soheil Ebrahimpour
Babol University of Medical Science
Author Profile

Abstract

Remdesivir has appeared to be the most effective medication against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is broadly administered to the coronavirus disease 2019 (COVID-19) patients around the world. Remdesivir is an RNA polymerase inhibitor with a broad spectrum of antiviral activities against RNA viruses in in-vitro and in-vivo models of SARS-CoV, the Middle East respiratory syndrome (MERS), and SARS-CoV-2. Remdesivir is the first Food and Drug Administration (FDA) approved anti-SARS-CoV-2 treatment for adult and pediatric patients and has been used intravenously for patients requiring hospitalization for COVID-19. However, questions have been raised about the value of remdesivir in treating COVID-19, and governing bodies worldwide have been hesitant to approve this medication. Nevertheless, in the context of the public health emergency and the urgent need for effective treatments for patients with COVID-19, remdesivir has been approved by several authorities worldwide. Here, we discuss the characteristics and applications of remdesivir, and various challenging studies with different outcomes about its efficacy are also reviewed.